In SURMOUNT-1, the population consisted of individuals with obesity or overweight who had what diabetes status?

In SURMOUNT-1, the population consisted of individuals with obesity or overweight who had what diabetes status?

• A. Without diabetes
• B. Only with diabetes
• C. Both with and without diabetes
• D. None

Answer: (A)

The question tests understanding of who was enrolled in SURMOUNT-1. This trial focused on adults with obesity or overweight who did not have diabetes at baseline. Why this matters: studying weight loss in a non-diabetic population helps ensure that any observed weight reduction is due to the weight-management medication itself, not influenced by diabetes medications or the metabolic effects of diabetes. Including people with diabetes could confound results because glucose-lowering therapies and diabetic physiology can independently affect weight. So the best description is that participants were without diabetes.

The question tests understanding of who was enrolled in SURMOUNT-1. This trial focused on adults with obesity or overweight who did not have diabetes at baseline. Why this matters: studying weight loss in a non-diabetic population helps ensure that any observed weight reduction is due to the weight-management medication itself, not influenced by diabetes medications or the metabolic effects of diabetes. Including people with diabetes could confound results because glucose-lowering therapies and diabetic physiology can independently affect weight. So the best description is that participants were without diabetes.