Which factor decreases leptin secretion?

Which factor decreases leptin secretion?

• A. Overfeeding
• B. Poor sleep quality
• C. Increased activity
• D. Warm ambient temperatures

Answer: (B)

Leptin, produced by fat cells, reflects energy stores and helps regulate appetite by signaling the brain. While leptin levels generally rise with greater fat mass, sleep quality has a strong, independent influence. When sleep is poor, circulating leptin decreases, which weakens the brain’s satiety signal and can lead to increased hunger and food intake. This makes poor sleep a common driver of lower leptin. In contrast, overfeeding increases leptin as fat stores expand, and while physical activity can affect energy balance, it does not lower leptin as reliably as sleep deprivation does. Warm ambient temperatures don’t have a strong, direct impact on leptin secretion compared with sleep.

Leptin, produced by fat cells, reflects energy stores and helps regulate appetite by signaling the brain. While leptin levels generally rise with greater fat mass, sleep quality has a strong, independent influence. When sleep is poor, circulating leptin decreases, which weakens the brain’s satiety signal and can lead to increased hunger and food intake. This makes poor sleep a common driver of lower leptin. In contrast, overfeeding increases leptin as fat stores expand, and while physical activity can affect energy balance, it does not lower leptin as reliably as sleep deprivation does. Warm ambient temperatures don’t have a strong, direct impact on leptin secretion compared with sleep.