Which statement about lorcaserin is most consistent with the source material?

Which statement about lorcaserin is most consistent with the source material?

• A. 5HT2B receptor high binding affinity
• B. Most commonly reported side effect is headache
• C. Dose is based on body weight
• D. It reduces appetite with a modest antidepressant effect

Answer: (B)

Lorcaserin acts by selectively activating 5-HT2C receptors in the hypothalamus to suppress appetite, and it is designed to have little activity on 5-HT2B to avoid valvular heart disease risks seen with other serotonergic weight-loss drugs. Dosing is fixed (not based on body weight), and while it can cause various adverse effects, the most commonly reported one is headache. The idea that it has a dose based on body weight is inaccurate, and it isn’t recognized for a meaningful antidepressant effect. So the statement that the most commonly reported side effect is headache best fits the known profile.

Lorcaserin acts by selectively activating 5-HT2C receptors in the hypothalamus to suppress appetite, and it is designed to have little activity on 5-HT2B to avoid valvular heart disease risks seen with other serotonergic weight-loss drugs. Dosing is fixed (not based on body weight), and while it can cause various adverse effects, the most commonly reported one is headache. The idea that it has a dose based on body weight is inaccurate, and it isn’t recognized for a meaningful antidepressant effect. So the statement that the most commonly reported side effect is headache best fits the known profile.