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  • In therapy for type 2 diabetes, the addition of insulin is most effective when combined with which oral agent?
  • During childhood and adolescence, how does body mass index typically change?
  • In a randomized trial of two calorie-deficit diets for individuals with metabolic syndrome, Diet A produced better triglyceride, glucose, and HDL outcomes, despite equal weight loss, due to what macronutrient difference?
  • By how much does all-cause mortality decrease after Roux-en-Y gastric bypass, largely due to reductions in cardiovascular and cancer mortality?
  • In the described patient with obesity and dyslipidemia (TG 210 mg/dL and LDL 152 mg/dL), which lipid abnormalities are present?
  • Which body composition component is the principal contributor to resting energy expenditure?
  • Which class of obesity medications does liraglutide belong to?
  • Which factor increases the risk of cardiovascular disorders in patients with obesity?
  • Which guideline body is commonly referenced for obesity management guidelines, including categorizing obesity severity and guiding therapy?
  • When should transition from titration to maintenance follow-up occur?
  • Which test is more sensitive for diagnosing diabetes and impaired glucose tolerance but is less convenient and is rarely used routinely except for gestational diabetes and research?
  • Which safety considerations are important when using GLP-1 receptor agonists for weight management?
  • Which statement best describes obesity management?
  • What minimum weight loss is needed to see therapeutic benefit across obesity-related comorbidities in this scenario?
  • In motivational interviewing, this response illustrates which technique?
  • In motivational interviewing, which question structure is used to draw out change talk by clarifying why a patient assigns a moderate importance rather than high?
  • What is the rationale for using anti-obesity medications as part of treatment?
  • Which alternative technique is commonly used when DEXA is not available to assess body composition?
  • In rhabdomyolysis, which laboratory finding is most characteristic?
  • Obesity is best defined as a chronic disease. Which statement best reflects this definition?
  • Which of the following is a contraindication to bariatric surgery?
  • This type of behavior therapy is referred to as limiting exposure to cues that trigger overeating?
  • In a structured diet plan, why might uncounted fruit servings lead to slower weight loss?
  • In a 45-year-old patient with obesity, elevated TSH and normal free T4, what is the best initial treatment?
  • In the context of very-low-calorie diets, when is such an approach appropriate?
  • Which incretin-based therapy has shown the greatest glucose-lowering efficacy and weight loss potential in trials?
  • Which statement about sleeve gastrectomy is true?
  • What is the shape of the relationship between birth weight and subsequent obesity based on the source findings?
  • Which statement best captures obesity pathophysiology?
  • Which statement about obesity treatment guidelines is most accurate?
  • Which obesity medication is contraindicated in a patient on monoamine oxidase inhibitors?
  • What is a commonly recommended practice when initiating GLP-1 receptor agonists to minimize GI side effects?
  • Which patient has an indication for antiobesity medication?
  • Which liver enzyme is commonly monitored to assess NAFLD response to weight loss?
  • What is a common consequence of obesity-related stigma in patient care?
  • How does set point theory influence long-term obesity treatment planning?
  • Adaptive thermogenesis is another name for which phenomenon observed after weight loss?
  • What BMI and comorbidity thresholds typically define eligibility for bariatric/metabolic surgery?
  • Which statement aligns with obesity management guidelines?
  • Which two GI side effects are commonly associated with orlistat and can affect adherence?
  • Which modality provides the most accurate measurement of multiregional body fat distribution?
  • In SURMOUNT-1, what was the weight loss at the highest tirzepatide dose compared with placebo?
  • Which statement about lorcaserin is most consistent with the source material?
  • Which statement about initial obesity evaluation is true?
  • Which of the following is a common adverse event with GLP-1 receptor agonists?
  • Which set of components defines metabolic syndrome that may improve with weight loss?
  • Which biological mechanism explains increased hunger on a low-calorie diet due to reduced signaling in the hypothalamus?
  • For a five-year-old adopted child with short stature and high weight percentiles, what is the most appropriate next step?
  • Which obesity pharmacotherapy should be used with caution due to risk of nephrolithiasis?
  • Phentermine/topiramate ER is contraindicated in which patient scenario?
  • Which strategy best supports maintaining weight loss after discontinuing pharmacotherapy?
  • Which statement about obesity as a disease is most accurate?
  • Which measurements should be determined to assess metabolic syndrome?
  • A 48-year-old woman six weeks after bariatric surgery presents with nausea, vomiting, edema, numbness, tingling in her feet, and brain fog. Which nutritional deficiency is most likely?
  • Name three metabolic risk factors that typically improve with weight loss.
  • What BMI threshold defines obesity in adults?
  • Which obesity medication is a once-weekly GLP-1 receptor agonist approved for weight management at 2.4 mg?
  • What is the general guideline regarding weight management pharmacotherapy during pregnancy?
  • What waist circumference thresholds are commonly used to indicate increased cardiometabolic risk?
  • Which class of medications includes liraglutide and semaglutide used for weight management?
  • Which strategy is used to promote SDM?
  • Which adverse effect on metformin led to switching to glyburide in this case?
  • What term describes the disproportionate decrease in resting metabolic rate after weight loss, contributing to weight regain?
  • What are the key elements of a patient-centered approach in obesity care?
  • What is the role of ghrelin in food intake regulation?
  • What counseling approach is emphasized to enhance readiness to change in obesity treatment?
  • According to Prochaska's Stages of Change, which stage describes a person who acknowledges weight-related health risks but has not yet started taking steps toward change?
  • According to AHA/ACC/TOS guidelines, what is a recommended approach for low-calorie dieting in terms of daily energy deficit or total intake for women?
  • In the 5A framework, which is the first step in managing overweight or obesity?
  • Which is a key component of pre-surgical evaluation for bariatric/metabolic surgery?
  • A 38-year-old man with type 2 diabetes who gained weight on glyburide and had improved HbA1c on metformin; after discontinuing glyburide, which medication would be most beneficial to add?
  • When discussing weight with a patient, which term is recommended to minimize stigma?
  • Which statement about bariatric surgery in the United States is true?
  • Bariatric surgery is considered for patients with which weight criteria?
  • Describe the mechanism of action of phentermine/topiramate in obesity treatment and the main safety concern.
  • In screening for metabolic syndrome, which laboratory test is most appropriate given a family history of type 2 diabetes and a large waist circumference?
  • A GLP-1 receptor agonist was started in a patient who reports gastrointestinal issues. What is the best way to manage these common side effects?
  • What are the primary goals of a comprehensive obesity management program?
  • Which antihypertensive medication is most likely to explain a 5%-10% reduction in total energy expenditure?
  • Which weight-loss medication class would be most beneficial to add to the regimen in a patient who failed previous therapy, as described in the case?
  • What is the typical weight loss range after sleeve gastrectomy at 1 year?
  • Which obesity pharmacotherapy combines naltrexone and bupropion?
  • How do weight loss medications typically affect blood pressure?
  • Postoperative long-term complications after gastric bypass include significant weight regain and which of the following?
  • What is the general management sequence for a patient with obesity and NAFLD without cirrhosis?
  • What factors influence the choice between pharmacotherapy and bariatric surgery?
  • What is the typical percentage weight loss range within 1-2 years after Roux-en-Y gastric bypass?
  • What method is commonly used to measure body composition changes during weight management trials?
  • In a study of calorie-deficit diets with matched weight loss, which macronutrient modification was associated with improved triglycerides and HDL?
  • Name the three common bariatric procedures and state how each achieves weight loss.
  • What are key considerations for bariatric surgery in adolescents with severe obesity?
  • What is the impact of patient stigma on obesity care, and what strategy effectively mitigates it?
  • Which test is best to confirm a diagnosis of diabetes mellitus in a patient with classic symptoms and signs?
  • Which obesity medication is a once-daily injectable GLP-1 receptor agonist dosed at 3.0 mg for weight management and carries a boxed warning for thyroid C-cell risk?
  • Four weeks after starting weight loss counseling for a child with BMI in the 98th percentile, weight loss occurred without increased activity. What is the most appropriate next step?
  • Which biochemical tests should be ordered for a patient one year after Roux-en-Y gastric bypass?
  • Which syndrome may occur in association with thiamine deficiency after Roux-en-Y gastric bypass?
  • In head-to-head trial comparing tirzepatide to semaglutide, which had greater HbA1c reduction and weight loss at similar doses?
  • In a patient considered for lorcaserin, the drug should be used with caution in the presence of which condition?
  • What is the typical percent weight loss after Roux-en-Y gastric bypass at 2 years?
  • How does sleep influence obesity risk?
  • A patient who recently underwent Roux-en-Y gastric bypass presents five days later with abdominal pain radiating to the chest, tachycardia, and leukocytosis. Which complication is most likely?
  • What strategy supports maintaining weight loss after discontinuing pharmacotherapy?
  • Which lab tests are routinely monitored to assess diabetes risk/control during weight management?
  • Which metabolic risk factor is commonly improved with weight loss?
  • What two elements are essential to reduce weight regain long-term?
  • What is a major contraindication to initiating phentermine/topiramate therapy?
  • According to ADA guidelines, which diabetes medication class is associated with the most weight loss?
  • Which of the following is not typically considered when deciding between pharmacotherapy and bariatric surgery?
  • What does the term 'set point' refer to in obesity?
  • Which statement best describes the relationship between weight loss and improvement in comorbidities?
  • What preoperative assessment is essential before bariatric surgery to assess mental health and eating behavior?
  • Based on the Weight Watchers example, how many additional daily calories are from uncounted fruit if 6 servings per day are consumed?
  • What is weight cycling and what are its potential health implications?
  • Which measurements are needed to calculate the body mass index (BMI)?
  • In public health messaging, obesity has become the leading cause of which of the following?
  • Postprandial thermogenesis accounts for about what percentage of daily energy expenditure in a typical adult?
  • Which measurement is used alongside BMI to assess central adiposity and cardiometabolic risk?
  • Which factor best predicts the effectiveness of weight loss interventions?
  • For a 45-year-old woman with BMI 31.5 starting a weight-loss plan, which dietary target best aligns with guidelines?
  • Which factor decreases leptin secretion?
  • Short-acting insulin secretagogues (eg, repaglinide, nateglinide) are especially effective for which outcome?
  • How should adverse effects encountered with weight loss pharmacotherapy be managed?
  • What is a goal of shared-decision making?
  • Which of the following is commonly recommended as an initial weight loss goal to improve cardiometabolic risk?
  • After initial weight loss, what maintenance weight change range is generally considered stable?
  • Which statement best describes the role of ongoing support in obesity treatment?
  • In the first year of obesity treatment, what is the typical follow-up visit frequency during medication titration?
  • A patient four weeks after Roux-en-Y gastric bypass presents with progressive nausea, vomiting, and dysphagia. Which complication should be suspected?
  • Which obesity medications carry boxed warnings about the risk of thyroid C-cell tumors?
  • Which statement about obesity genetics is true?
  • Which diabetes medication class is least associated with weight loss?
  • During a prolonged Roux-en-Y gastric bypass surgery, a patient develops dark urine with low urine output, edema, hyperkalemia, elevated creatinine, and very high CK. What is the most likely explanation for this patient’s acute renal failure?
  • How do electronically delivered weight loss programs compare to face-to-face interventions, according to guidelines?
  • What daily energy deficit is commonly recommended to achieve about 0.5-1 kg weight loss per week?
  • What is the maximum approved daily dose of orlistat for adults?
  • Which component is essential in the adolescent bariatric evaluation?
  • In counseling a patient about second-generation anti-obesity medications, which statement best reflects a shared-decision-making approach?
  • Which comorbidity tends to abate after bariatric surgery?
  • Which imaging modality is preferred for accurately assessing fat distribution across multiple regions?
  • Which procedure is being used increasingly in the United States as definitive treatment for severe obesity (BMI greater than 60)?
  • Which weight loss range is expected after sleeve gastrectomy at 1 year?
  • Why is the word obese often avoided when discussing weight with patients?
  • Which of the following is NOT a common GI adverse event associated with GLP-1 receptor agonists?
  • Metabolic syndrome is very common among older adults. Which statement about the prevalence is most accurate?
  • Which finding most strongly suggests sleep apnea in a patient with daytime sleepiness?
  • Which statement best describes the relationship between obesity and genetics in management?
  • What tool is used to categorize obesity severity and guide therapy in practice guidelines?
  • Which vitamins/minerals are most commonly deficient after bariatric surgery?
  • A 45-year-old Japanese-American man with a BMI of 23 kg/m2 and a waist circumference of 92 cm has a higher risk for type 2 diabetes compared with Caucasians. How should his risk be classified?
  • In SURMOUNT-1, the population consisted of individuals with obesity or overweight who had what diabetes status?
  • Which type of exercise is most effective for increasing basal metabolic rate?
  • In obesity with NAFLD, what laboratory monitoring is recommended during weight management?
  • Which obesity medication is a once-weekly GLP-1 receptor agonist approved for weight management?
  • Which statement best reflects the role of sleep quality in metabolic regulation?
  • Which drug is not used in the treatment of metabolic syndrome?
  • Which dietary pattern is consistently associated with favorable cardiovascular risk reduction and is commonly recommended in obesity management?
  • What is dumping syndrome and after which bariatric procedure is it most associated?
  • Based on Asian-specific BMI thresholds, this patient with BMI 27.8 would be categorized as which risk class?
  • Which effect is hypothesized to be mediated by GIP receptor activation in obesity therapies?
  • In the fasting state, which statement best describes changes in neurotransmitter circuits?
  • Approximately how many calories are expended in postprandial thermogenesis for a man who consumes 2,200 kcal per day?
  • Which statement about glycemic index is true?
  • Postoperative monitoring after bariatric surgery focuses on which of the following?
  • According to ADA guidelines, which race/ethnicity demographic has lower BMI cutoffs?
  • Which statement about HbA1c testing for diagnosing diabetes is true?
  • In managing metabolic syndrome, which measures are emphasized?
  • Which obesity medication carries an increased risk of nephrolithiasis and should be used with caution in patients with kidney stones?
  • Which laboratory test combination is appropriate to monitor vitamin D status, PTH, and B12 after bariatric surgery?
  • Which communication approach best aligns with patient-centered obesity care?
  • Which preexisting condition has been shown to go into remission in up to 62% of patients 6 years after Roux-en-Y gastric bypass?
  • In initial evaluation, which two conditions are commonly screened as secondary causes of obesity?
  • Excess abdominal fat is associated with which cluster of metabolic abnormalities?
  • What components should be included when initiating anti-obesity medications to maximize success?
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